[Amino acids content in the blood serum of patients with multiple sclerosis.]

[Article in Russian]

Ivanova EM, Barabanova MA, Muzlaev GG, Petropavlovskaia TA, Stoianova OV.

Source

Kubanskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Krasnodar.

Abstract

Content of amino acids in the blood serum using ion-exchange chromatography and a quantitative crystalloscopic "closed drop" method was measured in 105 patients with multiple sclerosis of different severity. The relation between the dynamics of content of glutamic, asparagine acids and glycine and the disease severity was determined. The highest level of glutamic acid was found in the patients with severe disease course. The dynamics of quantitative changes in the amino acid content was accompanied by the disturbance of blood serum structuration and appearance of selective micromorphotypes. The positive correlation between the severity of motor and coordination disorders and the increase in levels of glutamic acid and glycine in the severe cases was detected.